This is Yard Barker's Chris Mueller.
Injuries have been the dominant story so far in this NFL season, as multiple superstars have been lost for the year just two weeks in here, the three teams in the most trouble.
As a result, no team has been hit harder by the injury bug than the San Francisco 40 Niners.
And it isn't particularly close.
The Niners lost defensive lineman Nick Bosa and Solomon Thomas for the season to tourney a C L's.
That's just the beginning of their injury woes.
The defending NFC champions without George Kittle again this week.
Raheem Mostert won't play.
Tevin Coleman is also going to be out for some time, and Richard Sherman and Deebo Samuel are among several names on the short term injured reserve list.
It's not just that important players are missing for San Francisco, it's that several of them are.
Even Jimmy Garoppolo won't go against the Giants this weekend.
The net effect of all these injuries is to fundamentally alter the Niners identity and take away much of what makes them so good and even great.
They somehow managed to stay competitive through all this and fight through.
Kyle Shanahan is going to deserve some serious coach of the year consideration.
The Indianapolis Colts have had a balanced, talented roster for several years now, but it's once again being decimated by injuries.
Safety Malik Hooker is done for the season and possibly for his career in Indianapolis after tearing his Achilles tendon, which is the same injury that befell starting running back Marlon Mack in Week one.
Receiver Paris Campbell is going to miss time with a knee injury, and while Indianapolis has some depth, if they had managed so far to stay fully healthy, they'd have a much better chance of emerging from what's likely going to be a muddled A F C South.
Finally, the New York Giants won't have say Kwan Barkley for the rest of the season after he to tore his A c L.
The situation for the Giants isn't the same as San Francisco's or Indianapolis's, however.
New York probably wasn't going to contend for a playoff spot in 2020 no matter what, but this season was going to be an important one in terms of Daniel Jones development under center.
Not having Barkley is likely going to hurt his maturation and development process and make his life considerably more difficult Without a viable multipurpose threat in the backfield.
To take some attention away from opposing defense is Jones might well rise above the situation.
That would be the best case scenario for New York.
But don't be surprised, however, if he and the Giants struggle.
You haven't three teams who have already been decimated more than any other in the NFL by injuries just two weeks into the season for yard Barker, I'm Chris Mueller.